Psilocybe natalensis is a species of psilocybin mushroom in the family Hymenogastraceae. It is found in South Africa.[1] The specific epithet refers to its type locality in Natal. The species was described as new to science in 1995 by Jochen Gartz, Derek Reid, Michael Smith, and Albert Eicker.[2] It is very closely related to Psilocybe cubensis, and differs in its habitat preference, less persistent annulus and genetic sequence